Our Technology

Our proprietary Mineral Coated Microparticle (MCM) technology was developed in the Bio-Inspired Materials Laboratory of our scientific founder and CSO, William Murphy, PhD., Professor of Biomedical Engineering & Orthopedics at UW-Madison.

 
 

MCM technology is a platform designed to mimic the natural properties of mineralized tissues (e.g. bones, teeth) to preserve and control the release of drug molecules without loss of function. The technology was patented by the Wisconsin Alumni Research Foundation (WARF). While artificial polymers traditionally have been used to encapsulate drugs for local sustained administration, this approach disrupts structure and function of the drug. MCM technology overcomes this limitation by providing a matrix that naturally stabilizes the drug, which then elutes in a controlled manner as the coating dissolves. The MCM particle and coating are manufactured from generally recognized as safe (GRAS) materials in a scalable process, with properties that can be tailored to the drug and the intended application.

 
 
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Bone Mimetic

Mineralized tissues (e.g. bones, teeth) naturally incorporate and stabilize proteins and other molecules. This process can extend the half-life of proteins from minutes to centuries. We take advantage of this property by allowing drugs to bind within our MCM system and retain their function during drug release at the intended place and time.

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Formulation

Our proprietary manufacturing process is both simple and scalable. It utilizes inexpensive input materials that are naturally found in the body and generally recognized as safe (GRAS), such as calcium salts.

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MCM Platform

Drug molecules readily bind within the MCM particles, and the particles can be tailored for controlled drug dosage, release kinetics, and duration of delivery. The drug is released at the site of administration as the MCM surface dissolves. The approach is applicable to a broad range of drugs, including protein biologics and small molecules.

 

Technology Advantage

 

The traditional ‘gold-standard’ drug delivery system uses either polylactic-co-glycol acid (PLGA) or polyethylene glycol (PEG) and have their limitations, especially with biologics. As the data below displays, the MCM delivery system has longer sustained delivery capabilities than traditional systems.

Yu et al. Adv. Ma. ter 2017, VOL, 1701255